发明名称 |
LIGANDEN FÜR ASYMMETRISCHE DIHYDROXYLIERUNG: MEHRERE CINCHONA ALKALOID EINHEITEN GEBUNDEN AN EINEN ZENTRALEN HETEROZYKLISCHEN KERN |
摘要 |
Osmium-catalyzed methods of addition to an olefin are discussed. In the method of asymmetric dihydroxylation of the present invention, an olefin, a chiral ligand, an organic solvent, an aqueous solution, a base, a ferricyanide salt and an osmium-containing compound are combined. The chiral ligand is an alkaloid or alkaloid derivative linked to an organic substituent of at least 300 daltons molecular weight through a planar aromatic spacer group. The organic substituent can be another alkaloid or alkaloid derivative. With the described chiral ligands, asymmetric dihydroxylation of olefins with high yields and enantiomeric excesses are achieved. |
申请公布号 |
DE69233299(D1) |
申请公布日期 |
2004.03.11 |
申请号 |
DE1992633299 |
申请日期 |
1992.10.06 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE |
发明人 |
HARTUNG, JENS;SHARPLESS, BARRY |
分类号 |
C07B53/00;C07B61/00;C07C29/04;C07C29/48;C07C31/00;C07C33/26;C07C67/31;C07C69/675;C07C69/732;C07D453/02;C07D453/04;(IPC1-7):C07D453/04 |
主分类号 |
C07B53/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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