GENERATION OF DENDRITIC CELLS FROM CD34+ PRECURSORS

摘要

The present invention relates to a method for inducing development of dendritic cells from CD34+ precursor cells. More particularly, the present invention relates to a method of differentiating CD34+ precursor cells into myeloid- and or lymphoid-dendritic cells. The present invention provides a protocol for the development of dendritic cells from a biological sampleinte r alia cord blood, bone marrow or peripheral blood CD34+ stem cells. The dendritic cells of the present invention are useful as therapeutic cellular agents such as in the development of vaccines and in modulating immunologica l responsiveness. More particularly, the present invention provides compositio ns which can be used for inducing a protective immune response in a subject against inter alia pathogenic infections, autoimmune diseases and cancer.