| 摘要 |
The invention concerns a suspension of particles for carrying hydrophilic active principles (insulin). Said carrier particles are based on a polyethylene glycol/hydrophobic neutral polyminoacid double-block polymer. Said polyethylene glycol/hydrophobic neutral polyaminoacid particles are associated with a hydrophilic active principle (insulin). The invention also concerns, a powdery solid from which the transporting particles are derived and the preparation of said solid and said suspension of transporting particles based on polyethylene glycol/hydrophobic neutral polyminoacid particles and insulin. Said preparation consists in copolymerising N-carboxy-anhydrides of hydrophobic neutral polyminoacid particles, in the presence of N-methyl/pyrrolidone, methanol, and amine-functionalised polyethylene glycol, thereby obtaining polyethylene glycol/hydrophobic neutral polyaminoacids, associating the latter with insulin; precipitating with water so as to obtain the carrier particles; optionally carrying out neutralisation, dialysis, concentration and elimination of water, thereby producing a powdery solid or suspended carrier particles and preparing pharmaceutical specialties.
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