摘要 |
The present invention is directed to stable formulations of modified antibodies, each comprising an antibody fragment in an aqueous solution covalently attached to at least one nonproteinaceous polymer, such as @>lC(ethyleneglycol), through 0 succinimide moiety. CDP870 is an example of one such modified antibody. The formulations of the present invention include 0 buffer that maintains the solution at 0 pH of 3.5 to about 6, wherein all components of the modified antibody, including 0 succinimide ring of the succinimide moiety, are stable. |
申请人 |
PHARMACIA CORPORATION;JOHNSON, ROBERT, E.;QI, HONG;BORGMEYER, JEFFRY, R.;KESSLER, ROBERT, KENDALL;ZENG, DAVID, L. |
发明人 |
JOHNSON, ROBERT, E.;QI, HONG;BORGMEYER, JEFFRY, R.;KESSLER, ROBERT, KENDALL;ZENG, DAVID, L. |