发明名称 |
Combination therapy using a TNF binding protein for treating TNF-mediated diseases |
摘要 |
The invention relates to methods for treating or preventing acute and/or chronic arthritis. The method comprises administering to patients in need thereof therapeutically effective amounts of a TNF binding protein and methotrexate (N-[4-[[2,4-diamino-6-pteridinyl)methylamino]benzoyl]-L-glutamic acid). In a-preferred embodiment, the TNF binding protein is sTNFR-I or sTNFR-II. The invention also relates to pharmaceutical compositions containing a TNF binding protein and methotrexate useful in such methods. |
申请公布号 |
US2004047863(A1) |
申请公布日期 |
2004.03.11 |
申请号 |
US20030621783 |
申请日期 |
2003.07.16 |
申请人 |
AMGEN INC. |
发明人 |
BENDELE ALISON M.;SENNELLO REGINA M.;EDWARDS CARL K. |
分类号 |
A61K45/00;A61K31/519;A61K38/00;A61K38/17;A61P19/02;A61P29/00;A61P43/00;C07K14/525;(IPC1-7):A61K39/395;A61K31/525 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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