发明名称 |
D and L etherlipid stereoisomers and liposomes |
摘要 |
A liposome having a lipid bilayer, where the lipid bilayer includes either the L or D stereoisomer of an ether lipid or a non-equal mixture of both. Most preferably the liposome also comprises (a) an underivatized phosphatidylcholine; (b) a sterol; (c) about 5-20 mole % of a phosphatidylethanolamine linked to a dicarboxylic acid at the ethanolamine group of the phosphatidylethanolamine, and (d) greater than about 10 mole % to less than about 30 mole % of either the L or D stereoisomer of an ether lipid. The liposome may be used as an anti-cancer or anti-inflammatory agent.
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申请公布号 |
US2004047903(A1) |
申请公布日期 |
2004.03.11 |
申请号 |
US20030647382 |
申请日期 |
2003.08.26 |
申请人 |
ELAN PHARMACEUTICALS, INC. |
发明人 |
AHMED IMRAN;MAYHEW ERIC;JANOFF ANDREW |
分类号 |
A61K9/127;A61K9/133;A61K31/661;A61K45/00;A61K47/24;A61K47/28;A61P7/00;A61P31/04;A61P35/00;A61P35/02;A61P43/00;C07F9/10;(IPC1-7):A61K9/127 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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