发明名称 |
Selective destruction of cells infected with human immunodeficiency virus |
摘要 |
Compositions and methods for selectively killing a cell containing a viral protease are disclosed. The composition is a varient of a protein synthesis inactivating toxin wherein a viral protease cleavage site is interposed between the A and B chains. The variant of the type II ribosome-inactivating protein is activated by digestion of the viral protease cleavage site by the specific viral protease. The activated ribosome-inactivating protein then kills the cell by inactivating cellular ribosomes. A preferred embodiment of the invention is specific for human immunodeficiency virus (HIV) and uses ricin as the ribosome-inactivating protein. In another preferred embodiment of the invention, the variant of the ribosome-inactivating protein is modified by attachment of one or more hydrophobic agents. The hydrophobic agent facilitates entry of the variant of the ribosome-inactivating protein into cells and can lead to incorporation of the ribosome-inactivating protein into viral particles. Still another preferred embodiment of the invention includes a targeting moiety attached to the variants of the ribosome-inactivating protein to target the agent to HIV infectable cells.
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申请公布号 |
US2004048784(A1) |
申请公布日期 |
2004.03.11 |
申请号 |
US20030618560 |
申请日期 |
2003.07.10 |
申请人 |
KEENER WILLIAM K.;WARD THOMAS E. |
发明人 |
KEENER WILLIAM K.;WARD THOMAS E. |
分类号 |
A61K36/47;A61K38/16;A61K47/48;(IPC1-7):A61K38/16;A61K35/78 |
主分类号 |
A61K36/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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