发明名称 IMPROVED PROCESS FOR PREPARATION OF RISPERIDONE
摘要 The invention is for an improved process for of production of risperidone of formula (I) which comprises the steps of : (a) reacting a halo compound with an oxime ín a solvent and a base at 10-40°C; (b) refluxing the reaction mixture of step (a) for 4- 10 hours; (c) adding base to the cooled refluxed mixture of step (b) whileto maintaining the temperature at 20-40°C for 10-18 hours; (d) filtering and drying the risperidone thus obtained and (e) optionally purifying risperidone obtained in step (d). The invention also discloses a new polymorphic variety of risperidone namely, risperidone form T1 having its characteristic X-ray diffraction pattern and IR data.
申请公布号 WO2004020439(A2) 申请公布日期 2004.03.11
申请号 WO2003IB03830 申请日期 2003.08.25
申请人 NADKARNI, SUNIL, SADANAND;SHAH, RAJIV, GHANSHYAM 发明人 NADKARNI, SUNIL, SADANAND;SHAH, RAJIV, GHANSHYAM
分类号 C07D471/04 主分类号 C07D471/04
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