发明名称 |
Method and Device For the Synthesis and the Analysis of Suppert-Bound Arrays of Oligomers, Especially of Primer Pairs for PCR, as well as Oligomer-Carrying Supports |
摘要 |
For synthesis of a support-bound array of oligomers with free ends A, whereby a temporary protecting group is provided on the 5'-OH end of the oligomers and permanent protecting groups on reactive side groups, it is proposed that the temporary protecting group is removed from the end B after combinatorial synthesis of the oligomers onto the support, the free ends B are then cross-linked even before splitting of the permanent protecting groups, then the covalent bond of the synthesised oligomers can be removed via the end A onto the support, resulting in free ends A, and a portion of the synthesised oligomers binds covalently to the support also after removal of the ends A from the support.
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申请公布号 |
US2004048252(A1) |
申请公布日期 |
2004.03.11 |
申请号 |
US20030203082 |
申请日期 |
2003.04.17 |
申请人 |
BREITLING FRANK;POUSTKA ANNEMARIE;GROSS KARL-HEINZ;BREITLING FRIEDER |
发明人 |
BREITLING FRANK;POUSTKA ANNEMARIE;GROSS KARL-HEINZ;BREITLING FRIEDER |
分类号 |
B01J19/00;C07B61/00;C07H21/00;C12Q1/68;C40B40/06;(IPC1-7):C12Q1/68;C12M1/34;B05D3/00 |
主分类号 |
B01J19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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