| 发明名称 |
METHOD OF INDUCING AN IMMUNE RESPONSE WITH A LIVE VENEZUELAN EQUINE ENCEPHALITIS VIRUS EXPRESSING A HETEROLOGOUS IMMUNOGEN |
| 摘要 |
<p>Novel attenuating mutations of Venezuelan Equine Encephalitis (VEE) are disclosed. Further aspects of the invention include an infectious VEE virus transcript encoded by cDNA clones, infectious VEE virus particles, and pharmaceutical formulations containing such infectious particles. Also disclosed are recombinant VEE virus containing a heterologous RNA segment.</p> |
| 申请公布号 |
EP0762894(B1) |
申请公布日期 |
2004.03.10 |
| 申请号 |
EP19950922131 |
申请日期 |
1995.05.26 |
| 申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
JOHNSTON, ROBERT E.;DAVIS, NANCY L.;SMITH, JONATHAN F.;GRIEDER, FRANZISKA B. |
| 分类号 |
C12N15/09;A61K39/00;A61K39/193;A61P31/12;C07H21/04;C07K14/155;C07K14/165;C07K14/18;C07K14/285;C12N7/00;C12N15/40;C12N15/86;C12R1/92;(IPC1-7):A61K39/193;A61K39/295;C12N7/01;C12N7/04 |
主分类号 |
C12N15/09 |
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