Stable oxazaphosphorine-2-mercaptoethanesulphonate formulations

摘要

Low toxicity, stable oxazaphosphorine-containing compositions are prepared by adding an oxazaphosphorine antineoplastic and a 2-mercaptoethanesulphonate to an aqueous solution of an etherified beta -cyclodextrin. The 2-mercaptoethanesulphonate can be added as an aqueous solution optionally containing an etherified beta -cyclodextrin. Preferably, the oxazaphosphorine antineoplastic is Ifosfamide, the 2-mercaptoethanesulphonate is Mesna and the etherified beta -cyclodextrin is 2-hydroxypropyl- beta -cyclodextrin.