发明名称 |
EMULSION FORMULATION USING IODIZED OIL AND CATIONIC POLYMER FOR EFFECTIVE DELIVERY OF PHYSIOLOGICALLY ACTIVE SUBSTANCE OR DRUG AND PRODUCTION THEREOF |
摘要 |
PURPOSE: A new oil-in-water type emulsion formulation using an oil phase contrast agent and a cationic polymer allowing effective delivery of a physiologically active substance such as a gene or a drug into cells is provided together with a method for production thereof. The gene or drug delivery formulation for topical application exhibits high transfection efficiency in desired targeted cells for a long period of time in the case of local gene delivery. CONSTITUTION: The complex formulation for effective delivery of a physiologically active substance such as a gene or a drug into targeted cells comprises 10 to 50% by weight of a cationic polymer and 50 to 90% by weight of iodized oils. The binding ratio of the physiologically active substance and cationic polymer is 1:1 to 1:2. The cationic polymer is selected from the group consisting of polylysine, dendrimer, linear polyethyleneimine, branched polyethyleneimine, chitosan, diethylaminoethyl-dextran, polydimethyl and aminoethylmethacrylate and the iodized oils are selected from the group consisting of iodized poppy seed oil, ethiodol and iodized soybean oil.
|
申请公布号 |
KR20040020679(A) |
申请公布日期 |
2004.03.09 |
申请号 |
KR20020052346 |
申请日期 |
2002.08.31 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
JUNG, HYE SEON;JUNG, SEO YEONG;KIM, YEONG JIN;KWON, IK CHAN |
分类号 |
A61K47/44;(IPC1-7):A61K47/44 |
主分类号 |
A61K47/44 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|