| 发明名称 |
Prodrugs activated by targeted catalytic proteins |
| 摘要 |
Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.
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| 申请公布号 |
US6702705(B1) |
申请公布日期 |
2004.03.09 |
| 申请号 |
US19950392407 |
申请日期 |
1995.02.22 |
| 申请人 |
IGEN INTERNATIONAL, INC. |
发明人 |
VON BORSTEL REID;CASADEI JAN M.;KAMIREDDY BALREDDY;KENTEN JOHN;MARTIN MARK T.;MASSEY RICHARD J.;NAPPER ANDREW D.;SIMPSON DAVID M.;SMITH RODGER;TITMAS RICHARD C.;WILLIAMS RICHARD O. |
| 分类号 |
A61K38/00;A61K38/43;C07C229/46;C07C229/48;C07C235/74;C07C271/24;C07C311/06;C07C311/19;C07C317/44;C07D205/085;C07D207/40;C07D207/404;C07F9/24;C07F9/30;C07F9/32;C07F9/40;C07F9/553;C07F9/6509;C07F9/6571;C07H15/252;C07H19/04;C07K14/55;C07K16/00;C07K16/10;C07K16/26;C07K16/44;C07K16/46;C12N9/00;C12Q1/25;G01N33/50;G01N33/531;G01N33/577;(IPC1-7):C12N9/00 |
主分类号 |
A61K38/00 |
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