发明名称 |
Anti-tissue factor antibodies with enhanced anticoagulant potency |
摘要 |
The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF antibodies of the present invention are designed to comprise a region binding to an epitope in the C-terminal macromolecular substrate binding region of TF.
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申请公布号 |
US6703494(B2) |
申请公布日期 |
2004.03.09 |
申请号 |
US20010802083 |
申请日期 |
2001.03.08 |
申请人 |
GENENTECH, INC. |
发明人 |
KIRCHHOFER DANIEL K.;LOWE DAVID G.;PRESTA LEONARD G. |
分类号 |
A61K31/727;A61K39/395;C07K16/28;C07K16/36;C12N15/12;C12N15/13;(IPC1-7):C12N15/13;C12N15/00;C07K16/24 |
主分类号 |
A61K31/727 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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