发明名称 Indolopyrrolocarbazole derivatives and antitumor agents
摘要 A compound represented by the formula or a pharmaceutically acceptable salt thereofwherein R represents an unsubstituted pyridyl, furyl or thienyl group, or a pyridyl, furyl or thienyl group each of which has one or more substituents selected from the group consisting of a hydroxyl group, a lower alkoxy group, a hydroxy lower alkyl group and a hydroxy lower alkenyl group except that when the pyridyl, furyl or thienyl group has a lower alkoxy group as a substituent, each of which simultaneously has another substituent selected from the group consisting of a hydroxyl group, a lower alkoxy group, a hydroxy lower alkyl group and a hydroxy lower alkenyl group, m represents an integer of 1 to 3, and G represents a beta-D-glucopyranosyl group, and the positions of substitution of the hydroxyl groups on the indolopyrrolocarbazole ring are the 1- and 11-positions, or the 2- and 10-positions, and an antitumore agent containing it as an effective ingredient.The compounds have a better antitumor action than known compounds having a similar structure.
申请公布号 US6703373(B1) 申请公布日期 2004.03.09
申请号 US20020070825 申请日期 2002.03.11
申请人 BANYU PHARMACEUTICAL CO., LTD. 发明人 KOJIRI KATSUHISA;KONDO HISAO;ARAKAWA HIROHARU;OHKUBO MITSURU;SUDA HIROYUKI
分类号 C07H15/00;C07H19/00;C07H19/22;(IPC1-7):A01N43/04;A61K31/70 主分类号 C07H15/00
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