SURROGATES FOR TARGETS AND IMPROVED REFERENCE PANELS

摘要

A method to determine reactivity of a candidate compound with a target which method does not require the physical presence of the target is disclosed. By providing a formula for treating data obtained from a reference set of target substitutes which formula is p redictive of reactivity with the target, the compound to be tested can be physically a ssessed with respect to the reference panels, the formul a applied, and reactivity with the actual target may be predicted. Panels which consist of individual members, said members comprising proteins , wherein at least one of the members of the panel is a protein other than an immunoglobulin (Ig) or fragment thereof and wherein the presence of said non-Ig protein enriches the panel are described. These pane ls can be tested for reactivity with an analyte to creat e a profile. Such profiles can be used in pattern matching, analysis of samples and other analyses.