SYNTHETIC HEPARIN-BINDING GROWTH FACTOR ANALOGS

摘要

The invention provides synthetic heparin-binding growth factor analogs havin g at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin- binding domain, preferably by a linker, which may be a hydrophobic linker. T he synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.