发明名称 |
AMINO METHYL IMIDAZOLES AS C5A RECEPTOR MODULATORS |
摘要 |
<p>Amino methyl imidazoles of Formula (I) are provided: wherein R, Rl, R2, R3, R4, R5, and R6 are defined herein.Such compounds are ligands of C5a receptors. Preferred compounds of Formula (I) bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. Additionally, this invention provides labeled amino methyl imidazoles compounds, which are useful as probes for the localization of C5a receptors.</p> |
申请公布号 |
WO2004018460(A1) |
申请公布日期 |
2004.03.04 |
申请号 |
WO2003US26432 |
申请日期 |
2003.08.21 |
申请人 |
NEUROGEN CORPORATION;THURKAUF, ANDREW;ZHAO, HE;ZHANG, SUOMING;GAO, YANG |
发明人 |
THURKAUF, ANDREW;ZHAO, HE;ZHANG, SUOMING;GAO, YANG |
分类号 |
A61P29/00;A61P37/00;C07D401/12;C07D403/12;C07D405/12;C07D405/14;(IPC1-7):C07D405/12;A61K31/417 |
主分类号 |
A61P29/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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