METHODS FOR CREATING RECOMBINATION PRODUCTS BETWEEN NUCLEOTIDE SEQUENCES

摘要

The invention is directed to the creation of a collection of recombination products between two or more nucleotide sequences. The nucleotide sequences can encode distinct amino acid sequences and the collection of recombination products can be expressed to obtain a corresponding collection of polypeptide recombination products or variants. The amino acid sequences encoded by the two or more nucleotide sequences can correspond to polypeptides that are similar in function, but are encoded by dissimilar nucleotide sequences that cannot be recombined using traditional methods of recombination, which require a high degree of sequence similarity.