发明名称 |
ANTI-INFLAMMATORY EFFECT OF RADIX STEPHANIAE EXTRACT |
摘要 |
<P>PROBLEM TO BE SOLVED: To provide a biologically active substance having antiinflammatory effects with low toxity. <P>SOLUTION: The extract of characteristic ingredient of Radix Stephaniae tetrandrae (SPRST) has the antiinflammatory effects. The antiinflammatory effects of the SPRST is the result of mutual action of Tetrandrine, Fangchinokine and other effective ingredients. The SPRST is a special extract of the Chinese medicine having antiinflammatory effects with low cytotoxicity. The SPRST carries out upregulation of calcium influx and generation of active oxygen (ROS) by G protein, and has the antiinflammatory effects and protective function to ishaemic-reperfusion injury by inhibiting occurrence of Mac-1 (CD11B/CD18) by up-regulation of heterophilic leucocyte. <P>COPYRIGHT: (C)2004,JPO |
申请公布号 |
JP2004067694(A) |
申请公布日期 |
2004.03.04 |
申请号 |
JP20030287220 |
申请日期 |
2003.08.05 |
申请人 |
TAISO SEIBUTSU KAGI KOFUN YUGENKOSHI |
发明人 |
CHIN KAIHO;SHU SEIJIN;CHIN IKUKYO |
分类号 |
C07D491/18;A61K31/4741;A61K31/4748;A61K36/00;A61K36/18;A61K36/59;A61K45/06;A61P9/10;A61P29/00;A61P43/00 |
主分类号 |
C07D491/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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