MODIFIED CYTOCHROME c OXIDASE AND MITOCHONDRIA

摘要

PROBLEM TO BE SOLVED: To modify an active hydrogen ion transfer activity of a cytochrome c oxidase of mitochondria.

SOLUTION: An aspartic acid residue at the 51st position from the N-terminus of a subunit I of the cytochrome c oxidase by utilizing a method (patent application number 2002-202279) for transferring a protein to the mitochondria, applied by the inventor, etc. The cytochrome c oxidase having the modified subunit I contains the modified subunit I in which the aspartic acid residue at the 51st position from the N-terminus of the amino acid sequence of the subunit I of the cytochrome c oxidase of a vertebrate or at the corresponding position is modified.

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