Transdermal therapeutic systems containing buprenorphine, useful in treating pain or urinary incontinence, also containing mu-, kappa- or delta-opioid receptor antagonist to reduce abuse potential

摘要

A trandermal therapeutic system (TTS) containing buprenorphine (I) (in base or salt form) additionally contains at least one mu-, kappa- or delta-opioid receptor antagonist (II) (optionally in the form of racemate, pure stereoisomers (especially enantiomers or diastereomers) or their mixtures in all proportions, base, acid, salt or solvate (specifically hydrate)).