A METHOD FOR TREATING ALLERGIC DISEASE AND ASTHMA BY RECOMBINANT ADENOVIRUS-AND ADENO-ASSOCIATED VIRUS-MEDIATED IFN-gamma GENE
摘要
The subject invention concerns an effective therapy for asthma, including allergic disease, using cytokine gene expression therapy. The subject invention further pertains to the use of adenovirus-mediated IFN-gamma (Ad-IFN-gamma) gene transfer to prevent or treat allergic disease and asthma, including associated conditions such as allergen-induced airway inflammation and airway hyperresponsiveness. The subject invention includes a method for effectively attenuating allergen-induced airway inflammation and airway hyperresponsiveness by administering to the respiratory tract Ad-IFN-gamma, to affect IL-12 and STAT-4 levels. The subject invention also provides compositions for gene therapy for asthma by the transfer of IFN-gamma
申请公布号
WO03074561(A8)
申请公布日期
2004.03.04
申请号
WO2003US06535
申请日期
2003.03.03
申请人
UNIVERSITY OF SOUTH FLORIDA;MOHAPATRA, SHYAM, S.;KUMAR, MUKESH;BEHERA, ARUAN, K.
发明人
MOHAPATRA, SHYAM, S.;KUMAR, MUKESH;BEHERA, ARUAN, K.