MICE MUTANT FOR Fc RECEPTORS AND METHOD OF TREATING AUTOIMMUNE DISEASE
摘要
Disclosed herein is a non-naturally occurring non-human vertebrate animal incapable of expressing a functional Fc receptor which may optionally be capable of expressing a protein which comprises a domain of a human Fc receptor, as well as DNA encoding such Fc receptor-based proteins. Also disclosed are in vivo methods for identifying proinflammatory agents that depend on a functional Fc receptor, in vivo methods for identifying proinflammatory agents that do not depend on a functional Fc receptor, and both in vivo and in vitro methods of identifying anti-inflammatory agents. Pharmaceutical compositions containing, and methods of treating inflammation with anti-inflammatory agents are also described.
申请公布号
WO9528959(A9)
申请公布日期
2004.03.04
申请号
WO1995US05171
申请日期
1995.04.24
申请人
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;RAVETCH, JEFFREY, V.;TAKAI, TOSHIYUKI;SYLVESTRE, DIANA;CLYNES, RAPHAEL;ONO, MASAO