PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ASTHMA

摘要

Preventive and/or therapeutic drugs for asthma containing as the active ingredient substances capable of suppressing the functions of GPR4 relating to signal transduction; and preventive and/or therapeutic drugs for asthma containing as the active ingredient nitrogen-containing tricyclic compounds represented by the general formula (I), quaternary ammonium salts thereof, or pharmacologically acceptable salts of both: (I) wherein R<1> is substituted or unsubstituted lower alkyl or the like; R<2> is hydrogen, substituted or unsubstituted lower alkyl, or the like; R<3> and R<4> are each independently hydrogen, lower alkyl, or the like; n is 0 or 1; X is -(CH2)2- or the like; and Y is a group represented by the general formula (II): (II) (wherein W is CH or nitrogen; Z<1> and Z<2> are each independently hydrogen, substituted or unsubstituted lower alkyl, or the like; and Z<3> is hydrogen, substituted or unsubstituted lower alkyl, or the like).