| 摘要 |
2-(n-butyl)-5-nitrobenzofuran derivatives are new. 2-(n-butyl)-5-nitrobenzofuran derivatives of formula (I) are new. R1 = H or 1-12C alkyl; R2 = fluorine, chlorine, bromine, iodine, 1-12C alkyl, 1-12C alkoxy, hydroxyl, NR3R4 or CONR3R4, COO-(1-12C-alkyl), -COO(4-24C-aryl), -COO(5-25C-arylalkyl), CO(1-12C-alkyl), CO(4-24C-aryl) or 1-12C-fluoroalkyl; R3, R4 = H or 1-12C-alkyl or NR3R4 as a whole is 4-12C cyclic amino, and n = 1, 2 or 3. Where n = 2 or 3, it is possible for two adjacent R2 substituents to be part of a fused ring system which in turn may optionally be substituted by the radical. Provided the fused ring system is not 2-(n-butyl)-5-nitrobenzofuran. Independent claims are also included for: (1) Intermediate compounds of formula (II), (III), (V) , and (VII); (2) Preparation of (I); and (3) Treatment of cardiac arrhythmias involving administration of medicaments and physiologically active substances synthesized from intermediates (I).
|
