Process for the preparation of phosphites and complexes with transition metals

摘要

Method for preparing 1,1'-diaryl-2,2'-diyl-phosphites (I). Method for preparing 1,1'-diaryl-2,2'-diyl-phosphites of formula (I) comprises: (a) reacting phosphorus trihalide (II) with R1OH to form R1OP(halo)2 (IV); (b) purifying (IV) by distillation; and (c) reacting (IV) with D(OH)2 (V). D = optionally substituted 1,1'-(biphenyl or binaphthyl)-2,2'-diyl; R1 = 1-12C (halo)alkyl, 2-12C alkenyl, 5-15C aralkyl or 4-14C aryl, provided molecular weight is 215 or lower; and halo = bromo, iodo or (preferably) chloro. Independent claims are also included for the following: (1) preparation of transition metal complexes (C) by reacting (I) with a transition metal compound; (2) transition metal complexes of formulae (Xa), (Xb), (XI), (XII) and (XIII); and (3) method for producing stereoisometrically enriched compounds by asymmetric synthesis, using (C) as catalysts. ((I)4M1)An1 (Xa) ((I)2L2M1)An1 (Xb) ((I)4Hal2M12) (XI) ((I)2(Aren)Hal2Ru) (XII) ((I)2(XIV)Hal2Ru) (XIII) each (I) = same or different compound (I); M1 = rhodium or iridium; An1 = (trifluoro)methanesulfonate, tetrafluoroborate, hexafluoro-phosphate or -antimonate, perchlorate, tetra(bis-3,5-trifluoromethylphenyl)borate or tetraphenylborate; L = 2-12C alkene or both together form a 4-12C diene; Aren = 6-12C coordinated aromatic compound, optionally substituted by up to 6, same or different, 1-8C alkyl, benzyl or phenyl; (XIV) = NH2CR25R26-CR27R28NH2; R25-R28 = hydrogen, 1-12C alkyl, 4-14C aryl or 5-15C aralkyl, or two groups together form 3-12C alkylene.