1,4-SUBSTITUTED CYCLOHEXANE DERIVATIVES

摘要

Allylic compounds represented by the formula (I) are provided, (see formula I) wherein each of R1 to R8, m, n, A and X are as defined in the Specification. These compounds can inhibit Rho kinase, and can find utility in repair of damaged nerves in the central and peripheral nervous system by inducing axon growth and regeneration, and in t he treatment by inhibition of Rho kinase in disease states in which Rho kinase is implicated . The compounds are relatively cell permeable and pharmaceutical compositions thereof can promote neurite growth and are also useful for the prevention of cell proliferation in malignant deseases.