| 摘要 |
The present invention relates to a class of 2-aminothiazoline derivatives of formula I:in which either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk-NH2, -CH2-R3, -CH2-S-R4 or phenyl radical substituted with a nitro or -NH-C(=NH)CH3 radical, or R1 is an alkyl radical and R2 is a hydrogen atom, R3 is a (3-6C) cycloalkyl, pyridyl, pyridyl N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl or phenyl radical or a phenyl radical substituted with a nitro, hydroxy or carboxyl radical, R4 represents a pyridyl or pyridyl N-oxide radical, alk represents an alkylene radical, or pharmaceutically acceptable salts thereof, which are useful as inhibitors of inducible NO-synthase.
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