发明名称 Camptothecin analogue compounds
摘要 Compound of formula (I):wherein:n is 0, 1 or 2,R1 represents (C3-C11)cycloalkyl or (C3-C11)cycloalkylalkyl,R2, R3, R4 and R5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, carboxy, nitro, cyano, aminocarbonyl (optionally substituted), and the groups (CH2)p-NaRb and -O-C(O)-N-RaRb, with p, Ra and Rb being as defined in the description,or two adjacent groups R2, R3, R4 and R5 together form a group -O-(CH2)t-O, t being integer from 1 to 3,R60, R70n, R80 and R90 represent a hydrogen atom, a hydroxy group, an alkoxy group, or an O-(CO)-X or O-(CO)-NXW group as defined in the description,R61, R71n, R81, and R91 represent a hydrogen atom, alkyl, alkenyl or alkynyl, or taken in pairs together form a bond or an oxirane group, or two groups together form an oxo group.and medicinal products containing the same are useful for the treatment of cancerous disesases.
申请公布号 US6699876(B2) 申请公布日期 2004.03.02
申请号 US20020300330 申请日期 2002.11.20
申请人 LES LABORATOIRES SERVIER 发明人 LAVIELLE GILBERT;HAUTEFAYE PATRICK;PIERRE ALAIN;ATASSI GHANEM;HICKMAN JOHN;CIMETIERE BERNARD
分类号 A61K31/4745;A61P35/00;C07D471/14;(IPC1-7):A61K31/437 主分类号 A61K31/4745
代理机构 代理人
主权项
地址