发明名称 |
Assays for the detection of microtubule depolymerization inhibitors |
摘要 |
This invention provides assays for agents that modulate (e.g. upregulate, downregulate or completely inhibit) microtubule depolymerizing or microtubule severing proteins. Such agents will have profound effects on progression of the cell cycle and act as potent anti-mitotic agents. The microtubule severing protein or microtubule depolymerizing protein is preferably a katanin, a p60 subunit of a katanin, an XKCM 1, or an OP18 polypeptide.
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申请公布号 |
US6699969(B1) |
申请公布日期 |
2004.03.02 |
申请号 |
US20000724592 |
申请日期 |
2000.11.28 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
VALE RONALD D.;HARTMAN JAMES J. |
分类号 |
C12N9/14;C12Q1/42;G01N21/64;G01N33/68;(IPC1-7):C07K17/00;C12Q1/00 |
主分类号 |
C12N9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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