| 摘要 |
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of benzenesulfonamide of the formula (I): wherein X represents nitro- group, cyano-group or halogen atom; Y1 represents secondary or tertiary amino-group; Y2 represents nitrogen atom or group -NH; Z represents oxygen, sulfur atom, -N-CN or CH-NO2; R1 and R2 can be similar or different and each represents independently saturated or unsaturated linear or branched alkyl group comprising from 2 to 12 carbon atoms, saturated or unsaturated alicyclic group comprising from 3 to 12 carbon atoms, unsubstituted phenyl or phenyl substituted with one or some substituents representing (C1-C4)- alkyl group, nitro-, cyano-group, trifluoromethyl, carboxy-group and halogen atom, benzyl group or phenylethyl group; or Y1 means tertiary amino- -group and forms morpholine or homopiperidine with R1; Y2 represents nitrogen atom and forms homopiperidine with R2, with exception for derivatives wherein X means nitro-group, Y1 represents secondary amino-group (-NH-); Y2 represents group -NH; Z represents oxygen atom; R2 represents isopropyl; R1 is taken among the group including m-toluyl, phenyl and cyclooctyl, with exception N-[(2-cyclooctylamino-5-cyanobenzene)sulfonyl]-N'-isopropylurea, or its pharmacologically acceptable salts. Compounds of the formula (I) provides binding with thromboxane A2 receptors and can be used in pharmaceutical composition. EFFECT: valuable medicinal properties of compounds. 9 cl, 5 tbl, 3 sch, 2 ex |
