Methods and compositions for targeting an activated vitronectin receptor with a ligand comprising adenovirus-2 penton base or fragment thereof

摘要

Disclosed are ligands that can selectively bind to activated alpha v beta 3 integrin. A monovalent ligand- mimetic (WOW-1 Fab) which includes a single alpha v integrin-binding domain from multivalent adenovirus penton base is provided. Further disclosed are particular compositions of activated alpha v beta 3-specific ligands, such as an antibody which immunoreacts preferentially with activated alpha v beta 3 integrin. Also described are methods using an activated alpha v beta 3-specific ligand for diagnostic detection of activated alpha v beta 3 integrin in tissues and for the targeted delivery of therapeutic agents to tissues containing activated alpha v beta 3 integrin.