发明名称 |
Crystallised Fab'-epitope complex from the HIV-1 cross- neutralizing monoclonal antibody 2F5 |
摘要 |
The crystal structure of the Fab' fragment of Mab 2F5, a potent neutralizer of both laboratory strains and primary clinical isolates of most clades of HIV-1, both uncompleted and completed with the largely conserved peptide sequence ELDKWAS of the viral envelope protein gp41, has been elucidated and the characteristics of peptide-protein interactions determined. Having regard to such determination, the peptide-mimetics are constrained in the three-dimensional structure to provide an increased immunogenicity to the epitope sequence.
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申请公布号 |
NZ515356(A) |
申请公布日期 |
2004.02.27 |
申请号 |
NZ20000515356 |
申请日期 |
2000.04.05 |
申请人 |
UNIVERSITY OF TORONTO;AVENTIS PASTEUR LIMITED |
发明人 |
PAI, EMIL F;KLEIN, MICHEL H;CHONG, PELE;PEDYCZAK,ARTHUR |
分类号 |
C12P21/08;C07K7/06;C07K14/16;C07K16/10;C07K19/00;(IPC1-7):C07K14/16;C07K1/00 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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