| 摘要 |
FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to new methods for preparing compounds of the formula (I): wherein one group among R1 and R2 means cyclopropyl and another means phenyl substituted with two or three groups that can be similar or different and taken among halogen atom, nitro-, cyano-group, -(CR4R5)S(O)pR6, -S(O)pR6, C1-6-alkoxy-group, C1-4-haloalkoxy-group, C1-4-alkyl, C1-4- haloalkyl and -SF5; wherein p = 0, 1 or 2; R4 and R5 mean hydrogen atom independently or C1-4-alkyl; R6 means C1-4-alkyl. Method involves hydrolysis and decarboxylation of compound of the formula (II): wherein R1 and R2 are given above and R3 means C1-4-alkyl in the presence of water. Compound of the formula (II) is prepared by acylation of compound of the formula (III): wherein R1 and R3 are given above with compound of the formula (IV): R2C(= O)X (IV) wherein R2 is given above; X means removing group. Method is carried out in the presence of magnesium halide and a base. Compound of the formula (III) wherein R' means cyclopropyl is prepared by interaction of compound of the formula (V) wherein R1 means cyclopropyl and Y is substituted or unsubstituted imidazole-1-yl ring with compound of the formula (VI): wherein R3 is given above via decarboxylation of compound of the formula (VII): wherein R1 means cyclopropyl and R3 is given above. EFFECT: improved preparing methods. 19 cl, 9 ex |
