发明名称 |
New thio derivatives of gossypol or gossypolone, useful as anticancer agents, particularly for the treatment of solid tumors, or as intermediates in the synthesis of new gossypol or gossypolone derivatives |
摘要 |
New gossypol derivatives (I) comprise thio derivatives (especially 1,3-dithiolan or 1,3-dithian derivatives) of gossypol, gossypolone or gossypol methyl ethers. Gossypol derivatives of formula (I), preferably of formula (Ia) or (Ib), are new. A = O (in which case bonds d and f are double and bond e is single) or OH (in which case bonds d and f are single and bond e is double); W = when n2 = 0, W represents the functionality present in (Ia); or when n2 = 1, W represents the functionality present in (Ib); n2 = 0-1; n = 2-5 (preferably 2 or 3); Y = C-OH and Z' = CH (in which case bonds a and c are double and bond b is single); or Y, Z' = CO (in which case bonds a and c are single and bond b is double); R1 - R4 = H or 1-3C alkyl (preferably Me). Independent claims are also included for: (1) New compounds (I') comprising (I) bonded (optionally via a spacer) to a polymer (II) showing trophism for tumors; and (2) Preparation of (I).
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申请公布号 |
FR2843751(A1) |
申请公布日期 |
2004.02.27 |
申请号 |
FR20020010407 |
申请日期 |
2002.08.20 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS |
发明人 |
DAO VI THUY;GASPARD CHRISTIANE;MICHELOT ROBERT |
分类号 |
A61P35/00;C07D339/06;C07D339/08;C07D497/16;(IPC1-7):C07D521/00;C07D409/06;C07C49/172;C07C47/56;A61K31/385;A61K31/343;A61K31/39;A61K31/12;A61K31/11 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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