| 发明名称 |
Recombinant IL-18 antagonists useful in treatment of IL-18 mediated disorders |
| 摘要 |
A rodent neutralizing monoclonal antibody specific for human interleukin-18 and having a binding affinity characterized by a dissociation constant equal or less than about 3.9 x 10-11 M, and its use in treating autoimmune diseases.
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| 申请公布号 |
NZ513699(A) |
申请公布日期 |
2004.02.27 |
| 申请号 |
NZ20000513699 |
申请日期 |
2000.03.17 |
| 申请人 |
SMITHKLINE BEECHAM CORPORATION;SMITHKLINE BEECHAM PLC |
发明人 |
HO, YEN SEN;HOLMES, STEPHEN D;TAYLOR, ALEXANDER H;ABDEL-MEGUID, SHERIN S |
| 分类号 |
G01N33/53;A61K39/395;A61P1/04;A61P3/10;A61P17/06;A61P19/02;A61P25/00;A61P37/00;C07K16/24;C12N5/10;C12N15/02;C12N15/12;C12P21/08;C12R1/91;G01N33/577;(IPC1-7):C07K16/18;C12N5/12 |
主分类号 |
G01N33/53 |
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