摘要 |
1. A method for making 2- (N-phenylamino) benzoic acids, the method comprising the step of reacting a benzoic acid having the Formula I and an aniline having the Formula II with an alkaline metal hexamethyldisilazide to form a 2-(N-phenylamino) benzoic acid having the Formula III wherein each R is independently hydrogen, halogen, C1-C6 alkyl,-OC1-C6 alkyl, CN, or NO2. 2. The method of Claim 1 wherein the alkaline metal hexamethyldisilazide is lithium hexamethyldisilazide. 3. The method of any one of Claims 1-2 wherein the halo substituent in the 2 position of the benzoic acid is fluorine. 4. The method of any one of Claims 1-3 wherein the reaction is carried out at about -78 degree C to about 25 degree C in a polar aprotic solvent. 5. The method of Claim 4 wherein the polar aprotic solvent is tetrahydrofuran. 6. The method of any one of Claims 1-5 wherein the benzoic acid is 2,3,4-trifluorobenzoic acid and the aniline is 2-chloro-4-iodoaniline. 7. The method of any one of Claims 1-6 wherein the benzoic acid and the aniline are present in about a 1:1 molar ratio. 8. The method of Claim 1 wherein the electron donating group on aniline is -OCH3.
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