Method of screening for substance preventing or treating diseases in association with malfunction of il-6 family cytokine receptor malfunction

摘要

The invention provides a method of screening for substances preventing or treating diseases in association with IL-6 family cytokine receptor malfunction, which comprises using a transgenic mouse or a part thereof expressing a gp130 variant, wherein said gp130 variant comprises a substitution or a deletion of a tyrosine residue, which corresponds to the tyrosine residue at position 759 of human gp130 protein, or a substitution, an insertion or a deletion of one or more amino acid residues in a region comprising said tyrosine residue.