NEW PURINE DERIVATIVES

摘要

The present invention relates to compounds of formula (1) or pharmaceuticall y acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or mo re OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe , CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates t o pharmaceutical compositions comprising compounds of formula (1), and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.