N-ARYLPHENYLACETAMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

摘要

N-Arylphenylacetamide derivatives represented by the following formula [I]: (wherein R¹ is C_1-6 alkoxy, etc.; R² is hydrogen, -(CH₂)_m-N(R⁶)(R⁷) (m is an integer of from 1 to 4; R⁶ is hydrogen, C_1-4 alkyl, etc., R⁷ is hydrogen, etc.), etc.; R³ is hydrogen, halogen, etc.; R⁴ is C_6-10 alkyl, -Y-R⁸ (Y is a single bond, C_1-6 alkylene, C_2-6 alkenylene, C_2-6 alkynylene, etc., R⁸ is aryl, C_3-8 cycloalkyl, C_6-15 polycycloalkyl, etc.), etc.; R⁵ is hydrogen, etc.; and X¹ is hydrogen), or pharmaceutically acceptable salts thereof or hydrates or solvates of the same, and a pharmaceutical composition containing the same. These compounds are useful as preventives and/or remedies giving no pain at the early stage of administration, which are efficacious in oral administration and have potent analgesic and antiinflammatory effects.