A NON-INVASIVE DIAGNOSTIC TEST UTILIZING HISTONE MODIFICATION MARKERS
摘要
The present invention relates to the use of antibodies directed against specific histone amino terminus modifications as diagnostic indicators of disease or congenital defects. In one embodiment, nucleosomes are isolated from a blood or serum sample of a patient using histone specific antibodies and the accompanying DNA is purified and analyzed for diagnostic and screening purposes.
申请公布号
WO03070894(A3)
申请公布日期
2004.02.26
申请号
WO2003US04661
申请日期
2003.02.19
申请人
UNIVERSITY OF VIRGINIA PATENT FOUNDATION;CHROMA THERAPEUTICS LTD.;ALLIS, C., DAVID;BRUNS, DAVID, E.;DRUMMOND, ALAN, H.
发明人
ALLIS, C., DAVID;BRUNS, DAVID, E.;DRUMMOND, ALAN, H.