HYBRID INTERFERON/INTERFERON TAU PROTEINS, COMPOSITIONS AND METHODS OF USE

摘要

The present invention relates to hybrid interferon fusion proteins formed of an interferon- alpha protein where the C-terminal region of the interferon- alpha protein is replace by C-terminal region of interferon- tau . Also described are nucleic acid sequences encoding the interferon fusion proteins, expression vectors containing such sequences, and therapeutic applications of the interferon fusion proteins. The therapeutic applications include antiviral, anticellular proliferation, and anti-inflammatory applications. One advantage of the interferon fusion polypeptides of the present invention is that they have lower cytotoxic side effects when used to treat cells.