Polymer conjugates of hedgehog proteins and uses

摘要

A hedgehog polypeptide comprising hedgehog coupled to a polymer containing a polyalkylene glycol moiety wherein the hedgehog and the polyalkylene glycol moiety are arranged such that the hedgehog has an enhanced bioavailability relative to another hedgehog lacking the polymer and exhibits no decrease in activity as compared to non-conjugated hedgehog. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.