DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH CHEMOKINE RECEPTOR 8 (CCR8)

摘要

The invention provides a human CCR8 which is associated with the disorders of the peripheral and central nervous system, cardio-vascular diseases, gastro-intestinal diseases, cancer and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardio-vascular diseases, gastro-intestinal diseases, cancer and hematological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CCR8 as well as pharmaceutical compositions comprising such compounds.