Masp-2,a complement-fixing enzyme, and uses for it

摘要

The present invention relates to substantially pure mannin-binding lectin associated serine protease-2 (MASP-2) polypeptides and fragments thereof as well as nucleic acids encoding such polpeptides. Futhermone, the present invention realates to uses of a substantially pure polypeptide comprising amino acid sequences derived from mannan-binding lectin associated serine protease-2 (MASP2) or a functional homologue thereof for the production of a pharmaceutical composition as well as pharmaceutical compositons comprising MASP-2 and/or MASP-2 fragments. In addition the present invetion relates to inhibitors of MASP-2 and pharmaceutical compositiosn compring such inhibitors. Methods for detecting MASP-2 nucleic acid expression are included in the invention.