METHOD OF ESTIMATING DRUG METABOLIC ACTIVITY BY ANALYZING MUTATIONS IN GLUCURONOSYL TRANSFERASE GENE

摘要

It is intended to provide a method of judging, estimating or examining drug metabolism by effectively detecting mutations in a gene encoding UGT. Since a gene encoding UGT is made up of 5 exons and exons 2 to 5 are common in each UGT1 isoform, effective mutations in the UGT1 gene is examined by examining mutations in the common regions (in particular, mutations in the exon 5) and further detecting mutations in plural exon regions. To examine the mutations, use is made of nucleic acid chips with nucleic acid probes.