发明名称 |
Cyclopropyl and cyclobutyl epothilone analogs |
摘要 |
The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV wherein Ar is a radical represented by the following structure: and the other radicals and symbols have the meanings as defined herein; to their chemical synthesis and biological evaluation; their use in the treatment of neoplastic diseases and to pharmaceutical preparations containing such compounds. The compounds described herein are potent tubulin polymerization promoters and cytotoxic agents.
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申请公布号 |
US2004039026(A1) |
申请公布日期 |
2004.02.26 |
申请号 |
US20020227073 |
申请日期 |
2002.08.23 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
NICOLOOU KYRIACOS C.;NAMOTO KENJI;RITZEN ANDREAS;SHOJI MITSURU;ULVEN TROND;ALTMANN KARL-HEINZ |
分类号 |
A61K31/427;A61K31/4427;A61P35/00;A61P35/02;C07D313/00;C07D405/06;C07D405/12;C07D417/06;C07D417/12;C07D495/08;(IPC1-7):A61K31/443;C0745/02 |
主分类号 |
A61K31/427 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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