摘要 |
Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with some embodiments, there are provided fully human monoclonal antibodies directed to the antigen MCP-1. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided. |
申请人 |
ABGENIX, INC.;GUDAS, JEAN, M.;HAAK-FRENDSCHO, MARY;FOORD, ORIT;LIANG, MEINA, L.;AHLUWALIA, KIRAN;BHAKTA, SUNIL |
发明人 |
GUDAS, JEAN, M.;HAAK-FRENDSCHO, MARY;FOORD, ORIT;LIANG, MEINA, L.;AHLUWALIA, KIRAN;BHAKTA, SUNIL |