PYRROLIDINES WHICH INHIBIT CAMPSPECIFIC PDE.

摘要

Novel compounds (II) that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed. R1R7, R10 and R12 are as in the application.